When J. Jonah Jameson's astronaut son, John Jameson, brings a strange red gemstone back from the moon, he finds himself transformed into the macabre Man-Wolf! Becoming a lycanthropic creature on the loose, the Man-Wolf battles Spider-Man, Morbius, Kraven the Hunter and more - while investigator Simon Stroud comes ever closer to the Man-Wolf's true identity! Jameson soon discovers the truth behind the gem - but does his destiny lie in Other Realm wielding the sword of the Stargod? Or will the parasitic stone mean his destruction? Man-Wolf takes on Frankenstein's monster, She-Hulk and more - but can Spider-Man save him from a fate worse than death?
Collecting AMAZING SPIDER-MAN (1963) #124-125 and #189-190; GIANT-SIZE SUPER-HEROES #1; CREATURES ON THE LOOSE #30-37; MARVEL PREMIERE #45-46; MARVEL TEAM-UP (1972) #36-37; SAVAGE SHE-HULK #13-14 and material from PETER PARKER, THE SPECTACULAR SPIDER-MAN ANNUAL #3.